A shocking new study has sent alarm bells ringing across Pakistan — over 70% of young Pakistanis are obese, with many facing early heart attacks as young as 19. The first-of-its-kind PAK-SEHAT study has uncovered a silent health catastrophe brewing in the country, one that threatens to cripple the nation's youth unless immediate action is taken.
Led by Professor Bashir Hanif, a top interventional cardiologist in Karachi, the PAK-SEHAT (Pakistan Study of prEmature coronary aTHerosclerosis in young AdulTs) is Pakistan’s largest longitudinal study on heart disease risk in younger populations. Funded by Getz Pharma with Rs1.4 billion (approx. $5 million), this decade-long project is the country’s boldest attempt to understand why Pakistanis are suffering heart attacks in their 30s and 40s, far earlier than those in the West.
Unprecedented Obesity and Cholesterol Crisis
According to the study’s initial findings presented at the Pakistan Society of Internal Medicine (PSIM) Conference, more than 70% of participants were clinically obese, with obesity in women surging past 80%. Even more alarming, 70% had dangerously high LDL (“bad” cholesterol), while over 50% had abnormally low HDL (“good” cholesterol) levels.
"This level of cardiovascular risk in such a young population is unheard of,” said Prof. Hanif. “We’re now seeing heart attacks in people as young as 19 and 20 years old. This is not a global trend — it’s a uniquely Pakistani crisis."
The Hidden Killers: Undiagnosed Hypertension and Diabetes
The study also revealed that 42% of young adults had undiagnosed high blood pressure, and 23% had undetected diabetes. Many of these individuals had no prior symptoms, further emphasizing the urgent need for widespread screening and preventive healthcare programs.
These hidden conditions significantly raise the risk of coronary atherosclerosis, a condition where arteries become clogged with plaque, leading to heart attacks and strokes.
More Than Diet and Smoking: A Multifactorial Crisis
The PAK-SEHAT study goes beyond traditional heart disease factors like smoking and junk food. Researchers are also exploring how air and water pollution, genetics, poor urban infrastructure, and cultural dietary habits play a role in worsening heart health.
Participants are undergoing advanced coronary CT angiography (CCTA), inflammatory blood marker tests, and full genome sequencing to detect genetic predispositions specific to the South Asian population.
Why Western Models Don’t Work for Pakistan
Prof. Hanif strongly criticized the use of Western heart risk calculators in South Asia, stating that these tools underestimate risk in people under 40. “In the U.S., these tools start measuring heart risk after 60. In Pakistan, people are dying at 30 or even younger. We need a Pakistani-specific cardiovascular risk score now.”
Industry-Backed Health Transformation
Dr. Khurram Hussein, managing director of Getz Pharma, emphasized that the PAK-SEHAT study is more than just data collection — it’s about shifting Pakistan toward a patient-first, evidence-based healthcare system. “We want to break free from blindly following Western protocols,” he said, “and focus on research rooted in local realities.”
Former Punjab Health Minister Prof. Javed Akram applauded Getz Pharma for funding such transformative research, calling it essential for any real progress in national healthcare.
Urgent Call for Action
As the nation reels from these findings, experts are demanding nationwide health education campaigns, early screening programs, and school-based nutrition awareness. The youth of Pakistan is in crisis, and without bold, immediate interventions, the country could face a wave of premature deaths.
The study has laid bare an uncomfortable truth: Pakistan’s youth is dangerously unhealthy, and the country is on the brink of a massive public health disaster.
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